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If you need online voice capability or voice recognition, I'd go with a USB headset and bypass the sound card. You can spend $20-30 on a Logitech headset and get very good audio quality for Skype,...

I could make a suggestion or two, but not anything I'm very confident about. When I'm low on ideas, SFC /scannow is always worth a shot. You might also try the onboard sound or a different sound card...