2.5 drive as pc c drive question

Can a laptop hdd be used as a pc desktop master c:\ drive?

I have a 40 to 44 pin connectoralso have a usb ext closure

I want to load win 98 on the 2.5 drive that came out of a diagnistic machine
i thought that putting it in to a pc and doing the reload would work but i can not get the 2.5 to recognize on the pc desktop.

Are you sure pin1 on the connector is lined up with pin1 on the drive? Is it recognized in the BIOS?

no it doesnt show in bios

yet i can put it in a usb enclosure and boot with a floppy and get it to start load up of win then locks up

i can also use it as a second drive fine in the usb encloseue