When removing nasties I allways see that it's best to run in safe mode to remove these bad boy's, WHY? What is the reason for this?
Edit: Never mind but for those, like me, isn't sure why here is the explanation:
Spyware and adware vendors often use resuscitators, files that work to keep the adware/spyware infection active no matter how hard you - or the scanners - try to remove it. Booting into Safe Mode allows only the most essential processes to activate. While this won't guarantee all adware/spyware resuscitators will be killed, it does ensure the vast majority will be.
