My wife drives a '98 Honda Odyssey - runs like clock, and aside from a computer module covered under warranty, I don't anything has ever gone wrong with it. Gets about 20-22 mpg around town and 25+ on the highway. Drives much more like a car than the Caravans, etc., but I haven't tried the newer models (which are bigger).
If you don't need the seating for 7, I would also recommend Subaru. I've got a '96 Outback and its also been reliable as hell. The AWD will take you through anything and its got more ground clearance than most of the SUV's out there. Forester's got different shape but its the same drive train.
