I couldn't find the patch for it on the McAfee site but here's a list of ones that you can get for version 5 to work with.
http://download.mcafee.com/updates/vs5me_update.asp

I've been looking about McAfee's site for 4.5 info and patches lately and haven't seen squat on any non currect app besides the DAT files. If anyone see's any info on 4.5 and it's interactions with OS's please write me an e-mail.