R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = file://C:\DOCUME~1\Ghost\LOCALS~1\Temp\sp.html
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = file://C:\DOCUME~1\Ghost\LOCALS~1\Temp\sp.html
R1 - HKCU\Software\Microsoft\Internet Explorer\Search,SearchAssistant = file://C:\DOCUME~1\Ghost\LOCALS~1\Temp\sp.html
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Bar = file://C:\DOCUME~1\Ghost\LOCALS~1\Temp\sp.html
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = file://C:\DOCUME~1\Ghost\LOCALS~1\Temp\sp.html
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant = file://C:\DOCUME~1\Ghost\LOCALS~1\Temp\sp.html

If you don't know what those are I run SpyBot and Adaware and Hijack and what ever you have again , and are they all updated , like as of today or recently .