Yes the mouse works fine in safe mode.By the way that just boggles my mind how it could work just fine in safe mode but when it's in reg windows it wont? go figure .I don't know how to see if it works in dos mode.I plugged my brothers compaq mouse in to see if hardware manager could detect it and it detected my microsoft mouse lol go figure.Could I have a virus? when all this started it was colors/mouse/sound that didnt work one day when i turned on my comp.i've fixed alll but mouse .