Well, it's up to you, but the options come down to;

1: IF you can see the device in Device Manager;
. plug the drive in to the machine
. goto start, control panel,system,device manager
. scroll down to Universal Serial Bus controllers
. right click USB Mass Storage Device and delete driver.
. unplug the USB storage drive and plug it back in.

2:
.Unplug ALL USB devices except mouse.
.Open Device Manager
.View, Show Hidden Devices.
.Uninstall all devices under USB Controllers.
.Uninstall any USB disks from Disk Drives.
.Uninstall all devices under Storage Volumes. Say no to any reboot prompts until you are finished. Also, if a Storage Volume doesn't uninstall, ignore it and move to the next one.
.If you have a yellow ? with unknown devices, uninstall all of the entries there as well.
.When this is done, reboot TWICE
.Reconnect the USB devices and see if they're recognized properly.

3: EXTREME thing is obviously to do a complete CLEAN INSTALL, and then things will either be as they should or you'll know your motherboard has issues.

This means copying off EVERYTHING you value and making sure you know your internet and other passwords and DNS numbers and all that stuff.