MDK8 comes with the biggest support library of drivers ever. There are not many devices it won't automatically find, and install.
Winmodems are the hardest, there's very limited support, but most name brandNIC's and hard modems are supported. Motherboards, no problem. SCSI drives take a bit of fussing (especially on install) as well as DVD, but Cd-ROM's and burners are almost always configured upon install.
Post your hardware, and we can help out, or search around for the HCL on www.linux-mandrake.com